Transcriptions--usually brief line-a-day entries--originally entered into interleaved almanacs by members of the Holyoke family.

Receipted medical bill rendered from Dr. Edward Augustus Holyoke to William Northey for attendance and administration of medicines to the Northey family in Salem, Massachusetts, from September 9, 1779 to April 27, 1790.

Receipted medical bill rendered from Dr. Edward Augustus Holyoke to Joshua Pico for attendance and administration of sundry medicines to the Pico family in Salem, Massachusetts, from June 12, 1775 to July 10, 1776.

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it.

Correspondence from Dr. Edward Augustus Holyoke to Sir Charles Blagden (1748-1820), the Secretary of the Royal Society in London, England, concerning meteorology and Holyoke's observations about local climate and temperature.

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it.

Manuscript written by Dr. Edward Augustus Holyoke (1728-1829) regarding inoculation.